Cellulose based polymers have shown tremendous potential as drug delivery carrier for oral drug delivery system (DDS). Hydroxyethyl cellulose (HEC) and hydroxypropyl cellulose (HPC) are widely explored as excipients to improve the solubility of poorly water soluble drugs and to improve self-life of dosage form. This work is an attempt to modulate the physicochemical properties of these cellulose derivatives using biofield treatment. The treated HEC and HPC polymer were characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The XRD studies revealed a semi-crystalline nature of both the polymers. Crystallite size was computed using Scherrer’s formula, and treated HEC polymer showed a significant increase in percentage crystallite size (835%) as compared to the control polymer. This higher increase in crystallite size might be associated with greater crystallite indices causing a reduction in amorphous regions in the polymer. However treated HPC polymer showed decrease in crystallite size by -64.05% as compared to control HPC. DSC analysis on HEC polymer revealed the presence of glass transition temperature in control and treated HEC polymer. We observed an increase in glass transition temperature in treated HEC, which might be associated with restricted segmental motion induced by biofield. Nonetheless, HPC has not showed any glass transition. And no change in melting temperature peak was observed in treated HPC (T2) however melting temperature was decreased in T1 as compared to control HPC. TGA analysis established the higher thermal stability of treated HEC and HPC. CHNSO results showed significant increase in percentage oxygen and hydrogen in HEC and HPC polymers as compared to control samples. This confirmed that biofield had induced changes in chemical nature and elemental composition of the treated polymers (HEC and HPC).
1. Hearnden V, Sankar V, Hull K, Juras DV, Greenberg M, et al. (2012) New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Adv Drug Deliv Rev 64: 16-28.
2. Nicolazzo JA, Reed BL, Finnin BC (2005) Enhancing the buccal mucosal uptake and retention of triamcinolone acetonide. J Control Release 105: 240-248.
3. Al-Hilal TA, Alam F, Byun Y (2013) Oral drug delivery systems using chemical conjugates or physical complexes. Adv Drug Deliv Rev 65: 845-864.
4. Agarwal T, Narayana SN, Pal K, Pramanik K, Giri S, et al. (2015) Calcium alginate-carboxymethyl cellulose beads for colon-targeted drug delivery. Int J Biol Macromol 75: 409-417.
5. Liesiene J, Matulioniene J (2004) Application of water-soluble diethylaminoethylcellulose in oral drug delivery systems. Reactive Functional Polymers 59(2): 185-191.
6. Wang W, Wang J, Kang Y, Wang A (2011) Synthesis, swelling and responsive properties of a new composite hydrogel based on hydroxyethyl cellulose and medicinal stone. Composites: Part B : Engineering 42(4): 809-818.
7. Lin SB, Wu JH, Yao KD, Cai KY, Xiao CM, Jiang CJ (2004) Study of microstructure and properties of HEC-g-AA/SiO2 organic–inorganic hybrid materials. Composite Interface 11(3): 271-276.
8. Chen RN, Ho HO, Yu CY, Sheu MT (2010) Development of swelling/floating gastroretentive drug delivery system based on a combination of hydroxyethyl cellulose and sodium carboxymethyl cellulose for Losartan and its clinical relevance in healthy volunteers with CYP2C9 polymorphism. Euro J Pharma Sciences 39(1-3): 82-89.
9. Paradkar A, Kelly A, Coates P, York P (2009) Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry. J Pharm Biomed Anal 49: 304-310.
10. Sarode AL, Sandhu H, Shah N, Malick W, Zia H (2013) Hot melt extrusion for amorphous solid dispersions: temperature and moisture activated drug-polymer interactions for enhanced stability. Mol Pharm 10: 3665-3675.
11. Sarode AL, Malekar SA, Cote C, Worthen DR (2014) Hydroxypropyl cellulose stabilizes amorphous solid dispersions of the poorly water soluble drug felodipine. Carbohydrate Polymers 112: 512-519.
12. Warren DB, Benameur H, Porter CJ, Pouton CW (2010) Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility. J Drug Target 18: 704-731.
13. Trivedi MK, Tallapragada RR (2008) A transcendental to changing metal powder characteristics. Metal Powder Report 63(9): 22-28, 31.
14. Dabhade VV, Tallapragada RR, Trivedi MK (2009) Effect of external energy on atomic, crystalline and powder characteristics of antimony and bismuth powders. Bull Mater Sci 32: 471-479.
15. Trivedi MK, Tallapragada RR (2009) Effect of superconsciousness external energy on atomic, crystalline and powder characteristics of carbon allotrope powders. Mater. Res. Innovations 13(4): 473-480.
16. Trivedi MK, Patil S, Tallapragada RM (2012) Thought Intervention through Biofield Changing Metal Powder Characteristics Experiments on Powder Characterisation at a PM Plant, Springer Berlin Heidelberg, Editor : Wei Deng, Lecture Notes in Electrical Engineering-Future Control and Automation 173: 247-252.
17. Trivedi MK, Patil S, Tallapragada RM (2013) Effect of Biofield Treatment on the Physical and Thermal Characteristics of Vanadium Pentoxide Powders. J Material Sci Eng S11: 001.
18. Trivedi MK, Patil S, and Tallapragada RM (2013) Effect of bio field treatment on the physical and thermal characteristics of Silicon, Tin and Lead powders. J Material Sci Eng 2: 125.
19. Trivedi MK, Patil S, Tallapragada RM (2014) Atomic, Crystalline and Powder Characteristics of Treated Zirconia and Silica Powders. J Material Sci Eng 3: 144.
20. Trivedi MK, Patil S, Tallapragada RMR (2015) Effect of Biofield Treatment on the Physical and Thermal Characteristics of Aluminium Powders. Ind Eng Manage 4: 151.
21. Shinde V, Sances F, Patil S, Spence A (2012) Impact of Biofield Treatment on Growth and Yield of Lettuce and Tomato. Australian Journal of Basic and Applied Sciences 6(10): 100-105.
22. Sances F, Flora E, Patil S, Spence A, Shinde V (2013) Impact Of Biofield Treatment On Ginseng And Organic Blueberry Yield. Journal of Agricultural Science 35(1): 1991-8178.
23. Lenssen AW (2013) Biofield and Fungicide Seed Treatment Influences on Soybean Productivity, Seed Quality and Weed Community. Agricultural Journal 8(3): 138-143.
24. Trivedi M, Patil S (2008) Impact of an external energy on Staphylococcus epidermis [ATCC –13518] in relation to antibiotic susceptibility and biochemical reactions – An experimental study. Journal of Accord Integrative Medicine 4(4): 230-235.
25. Trivedi M, Patil S (2008) Impact of an external energy on Yersinia enterocolitica [ATCC –23715] in relation to antibiotic susceptibility and biochemical reactions: An experimental study. The Internet Journal of Alternative Medicine 6: 2.
26. Trivedi M, Bhardwaj Y, Patil S, Shettigar H, Bulbule A (2009) Impact of an external energy on Enterococcus faecalis [ATCC – 51299] in relation to antibiotic susceptibility and biochemical reactions – An experimental study. Journal of Accord Integrative Medicine 5(2): 119-130.
27. Patil SA, Nayak GB, Barve SS, Tembe RP, Khan RR (2012) Impact of Biofield Treatment on Growth and Anatomical Characteristics of Pogostemon cablin (Benth). Biotechnology 11: 154-162.
28. Kim UJ, Eom SH, Wada M (2010) Thermal decomposition of native cellulose: Influence on crystallite size. Polymer Degradation Stability 95(5): 778-781.
Cite this work
Researchers should cite this work as follows:
Trivedi MK, Nayak G, Patil S, Tallapragada RM, Mishra R(2015) Influence of Biofield Treatment on Physicochemical Properties of Hydroxyethyl Cellulose and Hydroxypropyl Cellulose. J Mol Pharm Org Process Res 3: 126. doi:10.4172/2329-9053.1000126