Biofield Energy Treatment: Physicochemical and Thermal Characterization of L-Tryptophan

By Dahryn Trivedi1, Mahendra Kumar Trivedi1, Alice Branton1, Gopal Nayak1, Snehasis Jana2

1. Trivedi Global Inc. 2. Trivedi Science Research Laboratory Pvt. Ltd.

Published on

Abstract

L-tryptophan is an essential amino acid that needs to be supplemented through protein-rich diet and it helps in growth and nitrogen balance in the humans. The aim of this study is to evaluate the effect of the Trivedi Effect®-Consciousness Energy Healing Treatment on the L-tryptophan in terms of its physicochemical and thermal properties by using modern analytical techniques. The method involved dividing the test sample into two parts and providing the Consciousness Energy Healing Treatment to one part (named as Biofield Energy Treated sample), remotely by a renowned Biofield Energy Healer, Dahryn Trivedi; while the other part didn’t receive any treatment called a control sample. The particle size values of the treated sample was increased by 4.77% (d10), 6.37% (d50), 6.72% (d90), and 6.49% {D(4,3)}; thus, the specific surface area was increased by 4.35% compared to the control sample. The PXRD peak intensities and crystal-lite sizes of the treated sample were significantly altered ranging from -82.69% to 30.54% and -17.15% to 179.73%, respectively, in comparison to the control sample. The total weight loss of the treated sample was significantly reduced by 11.60% during the heating process that resulted in a significant increase in the residual amount of the sample by 1093.33% as compared to the control sample. The melting temperature and the latent heat of fusion of the treated sample were significantly increased by 1.12% and 6.79%, respectively, compared to the untreated sample. Hence, the L-tryptophan might form a new polymorph after the Trivedi Effect®-Consciousness Energy Healing Treatment that may possess better solubility and bioavailability profile along with improved thermal stability compared with the untreated sample. Thus, the Trivedi Effect®-Consciousness Energy Healing Treatment could be considered as a novel approach for designing the formulations with improved drug profile and efficacy. The treated L-tryptophan would be more useful for the treatment of mental health disorders, premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), obsessive-compulsive disorder, depression, and bipolar disorder, etc.

References

1. Hopkins, F.G., Cole, S.W. A contribution to the chemistry of proteids: Part I. A preliminary study of a hitherto undescribed product of tryptic digestion. (1901) J Physiol 27(4-5): 418-428.
PubMed│CrossRef│Others

2. Ellinger, A., Flamand, C. Uber syntetischgewonnes tryptophan und einige seiner derivate. (1908) Hoppe-Selye’s Z Physiol Chemistry 55: 8-24.
PubMed│CrossRef│Others

3. Pardridge, W.M., Oldendorf, W.H. Kinetic analysis of blood-brain barrier transport of amino acids. (1975) Biochim Biophys Acta 401(1): 128-136.
PubMed│CrossRef│Others

4. Richard, D.M., Dawes, M.A., Mathias, C.W., et al. L-tryptophan: Basic metabolic functions, behavioral research and therapeutic indications. (2009) Int J Tryptophan Res 2: 45-60.
PubMed│CrossRef│Others

5. Young, V.R. Adult amino acid requirements: The case for a major revision in current recommendations. (1994) J Nutr 124(8 Suppl): 1517S-1523S.
PubMed│CrossRef│Others

6. Reilly, J.G., McTavish, S.F.B., Young, A.H. Rapid depletion of plasma tryptophan: A review of studies and experimental methodology. (1997) J Psychopharmacol 11(4): 381-392.
PubMed│CrossRef│Others

7. Sainio, E.L., Pulkki, K., Young, S.N. L-tryptophan: Biochemical, nutritional and pharmacological agents. (1996) Amino Acids 10(1): 21-47.
PubMed│CrossRef│Others

8. Matarese, L.E., Gottschlich, M.M. Proteins and amino acids. Contemporary Nutrition Support Practice, 2nded. Saunders, New York, 2003.
PubMed│CrossRef│Others

9. Friedman, M., Levin, C.E. Nutritional and medicinal aspects of d-amino acids. (2012) Amino Acids 42(5):1553-1582.
PubMed│CrossRef│Others

10. Herrera, C.P., Smith, K., Atkinson, F., et al. High-glycaemic index and -glycaemic load meals increase the availability of tryptophan in healthy volunteers. (2011) Br J Nutr 105(11): 1601-1606.
PubMed│CrossRef│Others

11. Richard, D.M., Dawes, M.A., Mathias, C.W., et al. L-tryptophan: Basic metabolic functions, behavioral research and therapeutic indications. (2009) Int J Tryptophan Res 2: 45-60.
PubMed│CrossRef│Others

12. Stone, T.W., Darlington, L.G. Endogenous kynurenines as targets for drug discovery and development. (2002) Nat Rev Drug Discov 1(8): 609-620.
PubMed│CrossRef│Others

13. Friedman, M. Analysis, Nutrition, and Health Benefits of Tryptophan. (2018) Int J Tryptophan Res 11: 1178646918802282.
PubMed│CrossRef│Others

14. Soh, N., Walter, G. Tryptophan and depression: Can diet alone be the answer? (2011) Acta Neuropsychiatr 23(1): 3-11.
PubMed│CrossRef│Others

15. Lindseth, G., Helland, B., Caspers, J. The effects of dietary tryptophan on affective disorders. (2014) Arch Psychiatr Nurs 29(2): 102-107.
PubMed│CrossRef│Others

16. Ledochowski, M., Sperner-Unterweger, B., Widner, B., et al. Fructose malabsorption is associated with early signs of mental depression. (1998) Eur J Med Res 3(6): 295-298.
PubMed│CrossRef│Others

17. Maron, E., Shlik, J., Nutt, D.J. Tryptophan research in panic disorder. (2008) Int J Tryptophan Res 1: 3-12.
PubMed│CrossRef│Others

18. Bowen, D.J., Spring, B., Fox, E.Tryptophan and high-carbohydrate diets as adjuncts to smoking cessation therapy. (1991) J Behav Med 14(2): 97-110.
PubMed│CrossRef│Others

19. Freeman, E.W., Sondheimer, S.J. Premenstrual dysphoric disorder: Recognition and treatment. (2003) Prim Care Companion J Clin Psychiatry 5(1): 30-39.
PubMed│CrossRef│Others

20. Mulla, S.I., Hu, A., Sun, Q., et al. Biodegradation of sulfamethox-azole in bacteria from three different origins. (2018) J Environ Manage 206: 93-102.
PubMed│CrossRef│Others

21. Andrysek, T. Impact of physical properties of formulations on bioavailability of active substance: current and novel drugs with cyclosporine. (2003) Mol Immunol 39(17-18): 1061-1065.
PubMed│CrossRef│Others

22. Trivedi, M.K., Branton, A., Trivedi, D., et al. Evaluation of the isotopic abundance ratio in biofield energy treated resorcinol using gas chromatography-mass spectrometry technique. (2016) Pharm Anal Acta 7: 481.
PubMed│CrossRef│Others

23. Trivedi, M.K., Branton, A., Trivedi, D., et al. Spectroscopic characterization of disodium hydrogen orthophosphate and sodium nitrate after biofield treatment. (2015) J Chromatogr Sep Tech 6: 282.
PubMed│CrossRef│Others

24. Berman, J.D., Straus, S.E. Implementing a research agenda for complementary and alternative medicine. (2004) Annu Rev Med 55: 239-254.
PubMed│CrossRef│Others

25. Barnes, P.M., Bloom, B., Nahin, R.L. Complementary and alterna-tive medicine use among adults and children: United States, 2007. (2008) Natl Health Stat Report 12: 1-23.
PubMed│CrossRef│Others

26. Trivedi, M.K., Patil, S., Shettigar, H., et al. Effect of biofield treatment on spectral properties of paracetamol and piroxicam. (2015) Chem Sci J 6: 98.
PubMed│CrossRef│Others

27. Trivedi, M.K., Tallapragada, R.M., Branton, A., et al. Potential impact of biofield treatment on atomic and physical characteristics of magnesium. (2015) Vitam Miner 3: 129.
PubMed│CrossRef│Others

28. Trivedi, M.K., Branton, A., Trivedi, D., et al. A Systematic study of the biofield energy healing treatment on physicochemical, thermal, structural, and behavioral properties of magnesium gluconate. (2017) Int J Bioorganic Chem 2(3): 135-145.
PubMed│CrossRef│Others

29. Trivedi, M.K., Patil, S., Tallapragada, R.M. Effect of biofield treatment on the physical and thermal characteristics of vanadium pentoxide powders. (2013) J Material Sci Eng S 11: 001.
PubMed│CrossRef│Others

30. Trivedi, M.K., Branton, A., Trivedi, D., et al. Gas chromatography-mass spectrometry based isotopic abundance ratio analysis of biofield energy treated methyl-2-napthylether (Nerolin). (2016) Am J Phy Chem 5(4): 80-86.
PubMed│CrossRef│Others

31. Trivedi, M.K., Tallapragada, R.M., Branton, A., et al. Characterization of physical and structural properties of aluminum carbide powder: Impact of biofield treatment. (2015) J Aeronaut Aerospace Eng 4: 142.
PubMed│CrossRef│Others

32. Trivedi, M.K., Branton, A., Trivedi, D., et al. Phenotyping and 16S rDNA analysis after biofield treatment on Citrobacter braakii: A urinary pathogen. (2015) J Clin Med Genom 3: 129.
PubMed│CrossRef│Others

33. Trivedi, M.K., Patil, S., Shettigar, H., et al. Evaluation of biofield modality on viral load of Hepatitis B and C viruses. (2015) J Anti-vir Antiretrovir 7: 083-088.
PubMed│CrossRef│Others

34. Trivedi, M.K., Patil, S., Shettigar, H., et al. An impact of biofield treatment: Antimycobacterial susceptibility potential using BAC-TEC 460/MGIT-TB System. (2015) Mycobact Dis 5: 189.
PubMed│CrossRef│Others

35. Trivedi, M.K., Branton, A., Trivedi, D., et al. Agronomic characteristics, growth analysis, and yield response of biofield treated mustard, cowpea, horse gram, and groundnuts. (2015) Int J Genetics Genom 3: 74-80.
PubMed│CrossRef│Others

36. Trivedi, M.K., Branton, A., Trivedi, D., et al. Evaluation of plant growth, yield and yield attributes of biofield energy treated mustard (Brassica juncea) and chick pea (Cicerarietinum) seeds. (2015) Agricult, Forestry Fisheries 4: 291-295.
PubMed│CrossRef│Others

37. Trivedi, M.K., Patil, S., Shettigar, H., et al. Phenotypic and bio-typic characterization of Klebsiella oxytoca: An impact of biofield treatment. (2015) J Microb Biochem Technol 7: 203-206.
PubMed│CrossRef│Others

38. Nayak G, Altekar N. Effect of biofield treatment on plant growth and adaptation. (2015) J Environ Health Sci 1(4): 1-9.
PubMed│CrossRef│Others

39. Trivedi, M.K., Patil, S., Shettigar, H., et al. In vitro evaluation of biofield treatment on cancer biomarkers involved in endometrial and prostate cancer cell lines. (2015) J Cancer Sci Ther 7: 253-257.
PubMed│CrossRef│Others

40. Singh, J., Trivedi, M.K., Branton, A., et al. Consciousness energy healing treatment based herbomineral formulation: A safe and ef-fective approach for skin health. (2017) Am J Pharmacol Phytother 2(1): 1-10.
PubMed│CrossRef│Others

41. Smith, D.M., Trivedi, M.K., Branton, A., et al. Skin protective activity of consciousness energy healing treatment based herbomineral formulation. (2017) J Food Nutr Sci 5(3): 86-95.
PubMed│CrossRef│Others

42. Koster, D.A., Trivedi, M.K., Branton, A., et al. Evaluation of biofield energy treated vitamin D3 on bone health parameters in human bone osteosarcoma cells (MG-63). (2018) Biochem Mol Biol 3: 6-14.
PubMed│CrossRef│Others

43. Trivedi, M.K., Sethi, K.K., Panda, P., et al. A comprehensive phys-icochemical, thermal, and spectroscopic characterization of zinc (II) chloride using X‑ray diffraction, particle size distribution, dif-ferential scanning calorimetry, thermogravimetric analysis/differ-ential thermogravimetric analysis, ultraviolet‑visible, and Fourier transform‑infrared spectroscopy. (2017) Int J Pharm Invest 7(1): 33-40.
PubMed│CrossRef│Others

44. Trivedi, M.K., Sethi, K.K., Panda, P., et al. Physicochemical, ther-mal and spectroscopic characterization of sodium selenate using XRD, PSD, DSC, TGA/DTG, UV-vis, and FT-IR. (2017) Marmara Pharm J 21(2): 311-318.
PubMed│CrossRef│Others

45. Desktop X-ray Diffractometer “MiniFlex+”. (1997) The Rigaku J 14: 29-36.
PubMed│CrossRef│Others

46. Zhang, T., Paluch, K., Scalabrino, G., et al. Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1Hinden-2-yl)-1H-in-den-1-ol. (2015) J Mol Struct 1083: 286-299.
PubMed│CrossRef│Others

47. Langford, J.I., Wilson, A.J.C. Scherrer after sixty years: A sur-vey and some new results in the determination of crystallite size. (1978) J Appl Cryst 11(2): 102-113.
PubMed│CrossRef│Others

48. Trivedi, M.K., Branton, A., Trivedi, D., et al. A systematic study of the biofield energy healing treatment on physicochemical, thermal, structural, and behavioral properties of iron sulphate. (2017) Int J Bioorganic Chem 2(3): 135-145.
PubMed│CrossRef│Others

49. Sun, J., Wang, F., Sui, Y., et al. Effect of particle size on solu-bility, dissolution rate, and oral bioavailability: Evaluation using coenzyme Q10 as naked nanocrystals. (2012) Int J Nanomedicine 7: 5733-5744.
PubMed│CrossRef│Others

50. Khadka, P., Ro, J., Kim, H., et al. Pharmaceutical particle tech-nologies: An approach to improve drug solubility, dissolution and bioavailability. (2014) Asian J Pharm 9: 304-316.
PubMed│CrossRef│Others

51. Trivedi, M.K., Branton, A., Trivedi, D., et al. Evaluation of the impact of biofield energy healing treatment (the Trivedi Effect®) on the physicochemical, thermal, structural, and behavioural properties of magnesium gluconate. (2017) Int J Nutr Food Sci 6(2): 71-82.
PubMed│CrossRef│Others

52. Savjani, K.T., Gajjar, A.K., Savjani, J.K. Drug Solubility: Impor-tance and Enhancement Techniques. (2012) ISRN Pharmaceutics 2012: 195727.
PubMed│CrossRef│Others

53. Mello, G.S., Cardoso, A.P., Oliveira, E.W.R.S., et al. Tryptophan. A proposal of the mechanism of thermal decomposition. (2015) J Therm Anal Calorim 122:1395–1401.
PubMed│CrossRef│Others

54. Mullany, L.C., Newton, S., Afari-Asiedu, S., et al. Cumulative effects of heat exposure and storage conditions of Oxytocin-in-Uniject in rural Ghana: implications for scale up. (2014) Glob Health Sci Pract 2(3): 285-294.
PubMed│CrossRef│Others

55. Jodar, K.S.P., Balcao, V.M., Chaud, M.V., et al. Development and Characterization of a Hydrogel Containing Silver Sulfadiazine for Antimicrobial Topical Applications. (2015) J Pharm Sci 104(7): 2241-2254.
PubMed│CrossRef│Others

56. Gheorghe, D., Neacsu, A.¸ Contineanu, I., et al. A calorimetric study of L-, D- and DL-isomers of tryptophan. (2017) J Therm Anal Calorim
PubMed│CrossRef│Others

57. Zhao, Z., Xie, M., Li, Y., et al. Formation of curcumin nanoparti-cles via solution enhanced dispersion by supercritical CO2. (2015) Int J Nanomedicine 10: 3171-3181.
PubMed│CrossRef│Others

Cite this work

Researchers should cite this work as follows:

  • Snehasis, J., et al. Biofield Energy Treatment: Physicochemical and Thermal Characterization of L-Tryptophan. (2019) J Anal Bioanal Separation Tech 4(1): 7- 13.
     

  • Dahryn Trivedi; Mahendra Kumar Trivedi; Alice Branton; Gopal Nayak; Snehasis Jana (2019), "Biofield Energy Treatment: Physicochemical and Thermal Characterization of L-Tryptophan," https://diagrid.org/resources/1930.

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